Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca. The two tumor tested cell lines used in this study were RD Human Embryonal Rhabdomyosarcoma cancerous cell lines: Cotula macroglossa Bolus ex Schltr.

Chemical composition and Anticandidal properties of the essential oil isolated from aerial parts of Cotula Cinerea: The results are expressed as percentage of cytotoxicity versus cofula concentrations of the essential oil or extracts of both plants. Retrieved 24 August Moreover, a molecule could have an effect on one type of tumor cinersa not on others. Another characteristic is their solitary heads growing on a peduncle.

Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot. In addition, these mixtures could act in a synergic or in an antagonism manner. Cell viability was evaluated by determination of the percentage of cytotoxicity using the formula given below. After filtration and evaporation of ethanol, the obtained aqueous solution was successively fractionated with hexane, ethyl acetate, and n -butanol. Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against RD cell line by MTT assay.

Evaluation of the Cytotoxicity Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy.

Flavonoids from Cotula cinerea Del

Sports Turf Research Institute. After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts hexane, ethyl cotlua, and n -butanol in addition to those of Salvia verbenaca.


In other projects Wikimedia Commons Wikispecies. Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.

Material and Methods 2.

Flavonoids from Cotula cinerea Del – Semantic Scholar

For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was cootula indicating a dose dependent effect. Prolonged cancer treatment is dinerea costly to patients and complicates patient follow-up in hospital. Morocco is rich in medicinal plants on which some studies have been focused on antitumor activities [ 7 — 10 ].

The plant is widely distributed in Morocco and is widely used in Moroccan traditional folk medicine as a cholagogue, antiseptic, diuretic, and astringent [ 12 ].

Indexed in Science Citation Index Expanded. The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil.

Essential oils are complex molecules containing various and several terpenoids compounds belonging mainly to monoterpene and sesquiterpene chemical groups and presenting different functional groups such as alcohols, phenols, ketone, etc. A potent fotula was thus observed for the Cotula cinerea hexane extract which inhibited the growth of RD cell line at the lowest IC 50 value This work was therefore initiated in order to evaluate the in vitro antiproliferative effect of Cotula cinerea and Salvia verbenaca extracts and essential oil against tumor RD and Vero cell lines.

This cnierea it difficult to define them by comparing their morphology. Showing of 22 references. On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with the lowest IC 50 value It is thus cinersa and imperative to find more effective drugs with a shorter application period.

Cabrera Cotula microglossa DC.

Burtt Cotula reptans Benth. Introduction Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ].


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The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis pathways and inactivating the telomerase [ 6 ]. After 30 minutes of incubation cinfrea room temperature, absorbance was measured at nm using an ELISA plate reader. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cotula cotuloides Steetz Druce Cotula cryptocephala Sch. Indeed, the explored extracts are complex mixtures containing several phytochemical compounds which could have different biological activities. Gymnogyne Steetz Peyrousea DC. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

Cotula – Wikipedia

The sections possess different basic chromosome numbers:. Cotula is the largest genus found in the Southern Hemisphere of the tribe Anthemideae.

In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts. These plants are widely used in the Moroccan traditional folk medicine.

The concentrations that inhibit half of the cell population IC 50 were obtained by modeling the percentage of cytotoxicity versus concentration of extracts. The maceration process was repeated twice during 24 h each in order to achieve an exhaustive extraction. Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially with the appearance of multidrug resistance cells.

Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs. The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight.