Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over cases per year in the. Akut Leukemia Limfoblastik Tipe – Download as Word Doc .doc), PDF File .pdf), Text File .txt) or read online. AKUT LIMFOBLASTIK LEUKEMIA. AkutLimoblastik Leukemia(LLA), gangguankeganasanproliferasiklonaldariprekursorlimfoid yang.

Author: Zulugar Vokora
Country: Georgia
Language: English (Spanish)
Genre: Travel
Published (Last): 8 September 2009
Pages: 147
PDF File Size: 11.95 Mb
ePub File Size: 14.25 Mb
ISBN: 128-1-83562-140-8
Downloads: 65355
Price: Free* [*Free Regsitration Required]
Uploader: Faektilar

Beberapa faktor lingkungan di ketahui dapat menyebabkan kerusakan kromosom dapatan, misal: Infant ALL is a rare variant that occurs in babies less than one year old. To view a copy of this license, visit http: Akibat defisiensi trombosit trombositopenia. Traditionally, risk stratification has been based on clinical factors such age, white blood cell count and response to chemotherapy; however, the identification of recurrent genetic alterations has helped refine individual prognosis and guide management.

Acute lymphoblastic leukemia – Wikipedia

Methods Mol Biol ; B-CD20 Limfovlastik is a B-lineage specific antigen expressed at nearly all stages of differentiation on the surface of both normal and malignant B-cells. This work is licensed under a Creative Commons Attribution 4. Leukemia, annual incidence rates acute lymphocytic leukemia.

D ICD – Cytogenetic analysis has shown different proportions and frequencies of genetic abnormalities in cases of ALL from different age groups.

Atul, Mehta dan A. Risk stratification allows the physician to determine the most appropriate initial treatment regimen as well as when to consider allogeneic stem cell transplantation Allo-SCT.


Acute lymphoblastic leukemia: a comprehensive review and update

In a case report, a young girl with her third-relapse of ALL was treated with a decitabine and dexamethasone regimen based on MDS dosing. Despite a reduction in CNS relapse and improved event-free survival, dexamethasone has increased risk of adverse events compared leukemiia prednisone.

Most of the clinical manifestations of ALL reflect the accumulation of malignant, poorly limfoblastk lymphoid cells within the bone marrow, peripheral blood, and, extramedullary sites. Novel targeted therapies offer the promise of effective anti-leukemic activity with reduced toxicity from off-target effects.

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

Studies 32 found that MRD-positivity is an independent risk factor for decreased relapse-free and overall survival. Mencegah terjadinya leukemia susunan saraf pusat. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Evidence suggests that secondary leukemia can develop in individuals treated with certain types of chemotherapy, such as epipodophyllotoxins and cyclophosphamide.

The rate of complete remission was significantly higher in the InO group versus standard chemotherapy High hyperdiploidy trisomy 4, 10, Leukemia is rarely associated with pregnancy, affecting only about 1 in 10, pregnant women.

Cycles were repeated every 22 days. Eosinofil merupakan fagositik yang lemah. Eosinofil memiliki granula sitoplasma yang kasar dan besar.

Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome—positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Preclinical studies have suggested a role for RNA-based methods with multiple infusions; however, all current clinical trials utilize a viral vector to deliver the CAR construct. Ribera JM, Oriol A.


Benign Osteoid osteoma Pigmented villonodular synovitis Hemangioma. The most significant adverse events include cytokine release syndrome CRS and hypotension.

Acute lymphoblastic leukemia

A prospective study of minimal residual disease in childhood B-lineage acute lymphoblastic leukaemia: MRD level at the end of induction is a strong predictive factor of relapse. It is a humanized monoclonal antibody conjugated to a pyrrolobenzodiazepine PBD. Other evaluation includes complete blood count with differential and smear to evaluate the other hematopoietic cell lines, coagulation profiles and serum chemistries.

Sel batang dapat dibagi ke dalam lymphpoid dan sel batang darah myeloiddimana pada kebalikannya menjadi cikal bakal sel yang terbagi sepanjang jalur tunggal khusus. Acute lymphoblastic leukemia ALL is the second most common acute leukemia in adults, with an incidence of over cases per year in the United States alone.

Dalam pengkajian dapt ditemukan adanya depresi, withdrawal, cemas, takut, marah, dan iritabilitas.